- GMRx2 is designed to deliver blood pressure-lowering benefits of triple combination therapy early in the treatment pathway, with an established safety profile
London, UK, 16 March 2026 – George Medicines, a late-stage biopharmaceutical company focused on addressing significant unmet needs in cardiometabolic disease, has entered into an exclusive licensing and supply agreement with Arrotex Pharmaceuticals (“Arrotex”), a leading Australian pharmaceutical company and Australia’s largest supplier of medicines by prescription volume, granting Arrotex exclusive rights to seek regulatory approval of, and to commercialize, GMRx2 in Australia.
GMRx2 is an innovative single pill combination of three medicines, telmisartan, amlodipine and indapamide, for the treatment of hypertension, developed in three doses, including two doses that are lower than those currently available in single pill combinations. By leveraging a multi-mechanism approach and lower doses, GMRx2 is formulated to deliver the blood pressure-lowering benefits of a triple combination therapy early in the treatment pathway, with the known safety profiles of existing antihypertensive medicines.
Under the terms of its licensing agreement, George Medicines will receive an upfront licensing fee and is eligible for commercial milestone payments, as well as a future recurring revenue stream through a tiered royalty rate on sales of GMRx2 in the licensed territory. In return, Arrotex is granted a license to exclusively commercialize GMRx2, supplied by George Medicines. Arrotex is responsible for seeking regulatory approval of GMRx2, supported by George Medicines, with upcoming applications to Australia’s Therapeutic Goods Administration and the New Zealand Medicines and Medical Devices Safety Authority.
Mark Mallon, Chief Executive Officer of George Medicines, said: “This latest partnership in our global commercialization strategy for GMRx2 signals our commitment to extend the reach of this triple combination product to all corners of the globe. The George Institute for Global Health, which founded George Medicines, was established in Australia and so it is a significant moment for us to bring GMRx2 one step closer to people living with hypertension in the Institute’s home country. As Australia’s largest pharmaceutical provider, and with its significant commercial capabilities, Arrotex is an ideal partner to support us in delivering on the potential of GMRx2 to help address key challenges in current hypertension treatment approaches.”
Monique Jonson, General Manager, Innovation, at Arrotex Pharmaceuticals, said: “Our partnership with George Medicines reflects Arrotex’s ongoing commitment to bringing innovative, life-changing therapies to Australia and New Zealand. Through our unprecedented operational and commercial capabilities, we are well placed to facilitate access for patients and look forward to working with the George Medicines team on our upcoming regulatory submissions for GMRx2.”
Around one in three adults in Australia (6.8 million) are living with high blood pressure with only half of those aware of their condition and receiving treatment. More than a million of those diagnosed and treated do not have their blood pressure effectively controlled1. In New Zealand, the prevalence of hypertension in adults is 31% (968,000), and only around a quarter have the condition effectively controlled2.
Most patients with hypertension will require two or more medicines to bring their blood pressure under control, and globally recognized treatment guidelines acknowledge the preferred use of single pill combination therapy and the benefit of their early use. 3,4,5
To date, George Medicines has granted licensing and supply agreements for GMRx2 in Brazil, Cananda, Mexico, Colombia and Central America, and the United States, with further collaborations anticipated as part of the Company’s commitment to bring the value of this important medicine to patients globally.
George Medicines is an independent spin-out company from The George Institute for Global Health, one of the world’s leading medical research institutes with a focus on addressing global health inequity. The Company is backed by George Health, the commercial arm of The George Institute, and Brandon Capital, Australia’s leading life sciences venture capital firm.
